abstract：:HOX genes are transcription factors that play important roles in body patterning and many cellular processes during embryonic, fetal, and adult development. Given their important function in normal tissues, it is reasonable to assume that abnormal expression of HOX genes in adults could lead to serious diseases such a...

journal_title：Biochemical and biophysical research communications

authors： Lee JY,Kim JM,Jeong DS,Kim MH

更新日期：2018-09-18 00:00:00

abstract：:Choroidal neovascularization (CNV) is a type of wet age-related macular degeneration (AMD) which is a major cause of blindness in elder patients. Tumor necrosis factor receptor-associated factor 6 (TRAF6) promotes tumor angiogenesis via upregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular e...

journal_title：Biochemical and biophysical research communications

authors： Ding D,Zhu M,Liu X,Jiang L,Xu J,Chen L,Liang J,Li L,Zhou T,Wang Y,Shi H,Yuan Y,Song E

更新日期：2018-09-18 00:00:00

abstract：:This study aims to investigate the clinical significance and biological function of RASSF6 in human breast cancers. RASSF6 protein was found to be downregulated in 42 of 95 human breast cancer tissues by immunohistochemistry, which was associated with advanced TNM stage and nodal metastasis. The rate of RASSF6 downreg...

journal_title：Biochemical and biophysical research communications

authors： He Z,Zhao TT,Jin F,Li JG,Xu YY,Dong HT,Liu Q,Xing P,Zhu GL,Xu H,Miao ZF

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:The anti-lung tumor potential of 11-carbonyl-β-boswellic acid was investigated. MATERIALS & METHODS:The inhibitory effects of 11-carbonyl-β-boswellic acid on non-small cell lung cancer (NSCLC) was assessed by proliferation, apoptosis, cell cycle and molecular mechanisms in NSCLC H446 cells in vitro. The res...

journal_title：Biochemical and biophysical research communications

authors： Huang G,Yang J,Zhang L,Cao L,Zhang M,Niu X,Zhou Z,Zhang X,Li P,Liu JF

更新日期：2018-09-18 00:00:00

abstract：:RAB3A interacting protein (Rab3IP) has been determined to be involved in cancer progression; however, its expression pattern and function in gastric cancer remain unknown. The aim of this study was to determine the association between Rab3IP and gastric cancer, in addition to its functional role in this disease. Overe...

journal_title：Biochemical and biophysical research communications

authors： Ren H,Xu Z,Guo W,Deng Z,Yu X

更新日期：2018-09-18 00:00:00

abstract：:ALIS are large, transient, cytosolic aggregates that serve as storage compartments for ubiquitin-tagged defective ribosomal products. We determined the importance of the protein p62 in the formation of ALIS and demonstrated that two domains of p62-PB1 and UBA-are essential for ALIS assembly. Those two major binding do...

journal_title：Biochemical and biophysical research communications

authors： Cabe M,Rademacher DJ,Karlsson AB,Cherukuri S,Bakowska JC

更新日期：2018-09-18 00:00:00

abstract：:Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. In previous studies, we have screened some aberrantly expressed lncRNAs from an animal model for DOX-indu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Li L,Li X,Wu S

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Research has indicated that Herba Patriniae can suppress the growth of Several kinds of tumor cells in vitro and in vivo, thus displaying favorable antitumor activity. However, research regarding the effect of saponins of Patrinia villosa against CRC cell has not been reported. In the current study, We have ...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Zhang B,Yan Q,Ruan S

更新日期：2018-09-10 00:00:00

abstract：:Oxidative stress plays an important role in the development of diabetic retinopathy. Here, we examined whether α-lipoic acid (α-LA), a natural antioxidant, attenuated retinal injury in diabetic mice. The α-LA was orally administered to control mice or mice with streptozotocin-induced diabetes. We found that α-LA reduc...

journal_title：Biochemical and biophysical research communications

authors： Kim YS,Kim M,Choi MY,Lee DH,Roh GS,Kim HJ,Kang SS,Cho GJ,Hong EK,Choi WS

更新日期：2018-09-10 00:00:00

abstract：:Retroviruses have two essential activities: reverse transcription and integration. The viral protein integrase (IN) covalently joins the viral cDNA genome to the host DNA. Prototype foamy virus (PFV) IN has become a model of retroviral intasome structure. However, this retroviral IN has not been well-characterized bio...

journal_title：Biochemical and biophysical research communications

authors： Mackler RM,Lopez MA,Osterhage MJ,Yoder KE

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:PTK6 is involved in cell proliferation, invasion and migration. Patients with lower PTK6 expression predicts poor prognosis of LSCC. However, the mechanism of PTK6 in LSCC progression remains unclear. We investigated the role of PTK6 in the pathogenesis of LSCC. METHODS:Human LSCC tissues and paired adjacen...

journal_title：Biochemical and biophysical research communications

authors： Wu D,Zhang X,Liu Z,Yan H,Mai J,Zhao Z,Zhong Q,Liu X

更新日期：2018-09-10 00:00:00

abstract：:Clinical attention to gluten-related disorders, such as celiac disease and nonceliac gluten sensitivity, is on the rise. However, identifying the pathophysiological mechanisms of gluten-related disorders remains elusive. Gliadin, a component of gluten, is known to play a major role in gluten toxicity. Caenorhabditis e...

journal_title：Biochemical and biophysical research communications

authors： Lim SD,Min H,Youn E,Kawasaki I,Shim YH

更新日期：2018-09-10 00:00:00

abstract：:Tumor necrosis factor receptor-associated factor 2 (TRAF2) has been demonstrated that it plays a significant role in cell death receptor signal transduction. The purpose of this study was to investigate the expression of TRAF2 and its possible role in FJOA. We observed an up-regulation of TRAF2 in FJOA by immunohistoc...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Zhang J,Wu C,Guo X,Chen C,Bao G,Sun Y,Chen J,Xue P,Xu G,Cui Z

更新日期：2018-09-10 00:00:00

abstract：:Antibody-dependent cell-mediated cytotoxicity bridges humoral immunity and cellular immunity. Thus vaccine candidates which can elicit both broadly neutralizing antibodies and potent antibody-dependent cell-mediated cytotoxicity (ADCC) are recommended. Previously, a panel of functional epitopes that can elicit ADCC ef...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Liu M,Ding N,Li Y,Shao J,Zhu M,Xie Z,Sun K

更新日期：2018-09-10 00:00:00

abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

journal_title：Biochemical and biophysical research communications

authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

更新日期：2018-09-10 00:00:00

abstract：:Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid peroxidation. While impaired ferroptosis is tightly linked to human diseases and conditions, the mechanism and regulation of ferroptosis remain largely unknown. Here, we demonstrate that STAT3 is a positive regulator of ferroptosi...

journal_title：Biochemical and biophysical research communications

authors： Gao H,Bai Y,Jia Y,Zhao Y,Kang R,Tang D,Dai E

更新日期：2018-09-10 00:00:00

abstract：:Tankyrases (TNKS and TNKS2) are enzymes that catalyze poly-ADP-ribosylation (PARsylation) of their target proteins. Tankyrase-mediated PARsylation plays critical regulatory roles in cell signaling, particularly in the Wnt/β-catenin pathway. The sterile alpha motif (SAM) domain in tankyrases mediates their oligomerizat...

journal_title：Biochemical and biophysical research communications

authors： Fan C,Yarravarapu N,Chen H,Kulak O,Dasari P,Herbert J,Yamaguchi K,Lum L,Zhang X

更新日期：2018-09-10 00:00:00

abstract：:Protein phosphatase 2Cs (PP2Cs) have been referred to act as negative modulators of the protein kinase pathways involved in different environmental stress responses and developmental processes. In Arabidopsis, PP2Cs have been extensively studied and some are known to negatively regulate abscisic acid signaling. In ric...

journal_title：Biochemical and biophysical research communications

authors： Amir Hossain M,Ahn CH,Lee IS,Jeon JS,An G,Park PB

更新日期：2018-09-10 00:00:00

abstract：OBJECTIVE:This study aimed to evaluate functions of APOBEC3F gene in biological process of hepatocellular carcinoma (HCC) and anti-tumor mechanisms of bufalin. METHODS:Effect of APOBEC3F and bufalin on cell proliferation and migration abilities were evaluated by CCK-8, wounding healing tests and transwell assays in SK...

journal_title：Biochemical and biophysical research communications

authors： Yang Z,Tao Y,Xu X,Cai F,Yu Y,Ma L

更新日期：2018-09-10 00:00:00

abstract：:Actin bundling protein 34 (ABP34) is the one of 11 actin-crosslinking proteins identified in Dictyostelium discoideum, a novel model organism for the study of actin-associated neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. ABP34 localizes at the leading and trailing edges of locomoto...

journal_title：Biochemical and biophysical research communications

authors： Chung JM,Kim HU,Kim GJ,Jeoung D,Jung HS

更新日期：2018-09-10 00:00:00

abstract：:Temperature is one of the primary environmental factors that affect aging, in which protein phosphorylation is an important regulator. Currently, the understanding of phosphorylation events in regulatory networks during aging has remained rather limited. Herein, the phosphoproteomes of C.elegans of different age group...

journal_title：Biochemical and biophysical research communications

authors： Huang J,Wu Z,Wang J,Zhang X

更新日期：2018-09-10 00:00:00

abstract：:The aim of the study was to determine the expression profiles of message RNAs and long non-coding RNAs in CD4+T cells of asthmatic patients and to explore the clinical value and biological function. Expression profiles in CD4+T cells of asthmatic patients and healthy controls were analyzed by microarray. We found 2725...

journal_title：Biochemical and biophysical research communications

authors： Qi X,Chen H,Huang Z,Fu B,Wang Y,Xie J,Zhao J,Cao Y,Xiong W

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:The functionality of lncRNA snaR has only been characterized in breast cancer and colon cancer. The aim of the current study is to explore the involvement of lncRNA snaR in ovarian carcinoma (OC). MATERIALS AND METHODS:Expression of lncRNA snaR and GRB2-associated binding protein 2 (GAB2) in plasma of both ...

journal_title：Biochemical and biophysical research communications

authors： Huang Y,Hu Y,Jin Z,Shen Z

更新日期：2018-09-10 00:00:00

abstract：:Isocitrate dehydrogenase 2 (IDH2) is an essential enzyme in the mitochondrial antioxidant system, which produces nicotinamide adenine dinucleotide phosphate, and thereby defends against oxidative stress. We have shown that IDH2 downregulation results in mitochondrial dysfunction and reactive oxygen species (ROS) gener...

journal_title：Biochemical and biophysical research communications

authors： Choi SJ,Piao S,Nagar H,Jung SB,Kim S,Lee I,Kim SM,Song HJ,Shin N,Kim DW,Irani K,Jeon BH,Park JW,Kim CS

更新日期：2018-09-10 00:00:00

abstract：:SPAK and OSR1 are two protein kinases that play important roles in regulating the function of numerous ion co-transporters. They are activated by two distinct mechanisms that involve initial phosphorylation at their T-loops by WNK kinases and subsequent binding to a scaffolding protein termed MO25. To understand this ...

journal_title：Biochemical and biophysical research communications

authors： Mehellou Y,Alamri MA,Dhiani BA,Kadri H

更新日期：2018-09-10 00:00:00

abstract：:Enhancer of Zeste 2 (EZH2) is the key enzymatic factor in Polycomb Repressive Complex 2 (PRC2), a transcriptional repressor which contributes to oncogenesis. Recent research has revealed the key role of aberrant EZH2 hyper-activity in human gliomas. Here, we examined the role of the lesser-known PRC2-associated PHD Fi...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Ji H,Tang H,Xu Z

更新日期：2018-09-10 00:00:00

abstract：:The production of therapeutic monoclonal antibodies is costly; therefore, antigen-binding fragments (Fabs) can be used instead. However, their tendency toward aggregation can reduce the half-life in the plasma and the therapeutic effectiveness. To examine the effect of glycosylation on the properties of the Fab of a t...

journal_title：Biochemical and biophysical research communications

authors： Nakamura H,Oda-Ueda N,Ueda T,Ohkuri T

更新日期：2018-09-05 00:00:00

abstract：:Ophiopogonin D (OPD) is the chief pharmacological active component of the traditional Chinese herbal prescription drug-Shenmai injection (SMI), which has been used to prevent and treat cardiovascular diseases. In the present study, we investigated whether OPD protectively relieve cardiac hypertrophy against inflammati...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Huang X,Ma Z,Wang Y,Chen X,Gao Y

更新日期：2018-09-05 00:00:00

abstract：:Brassica campestris Male Fertility 20 (BcMF20) is a typical zinc-finger transcription factor that was previously isolated from flower buds of Chinese cabbage (Brassica campestris ssp. chinensis). By applying expression pattern analysis, it can be known that BcMF20 was specifically and strongly expressed in tapetum and...

journal_title：Biochemical and biophysical research communications

authors： Han YY,Zhou HY,Xu LA,Liu XY,Fan SX,Cao JS

更新日期：2018-09-05 00:00:00

abstract：:Pulmonary fibrosis (PF) is a fatal respiratory disease with no effective medical treatments available. TGF-β/Smads signaling has been implicated to play an essential in the pathogenesis of PF, in which Smad3 act as the integrator of pro-fibrosis signals. In this study, we determined the effect of SIS3, a specific inhi...

journal_title：Biochemical and biophysical research communications

authors： Shou J,Cao J,Zhang S,Sun R,Zhao M,Chen K,Su SB,Yang J,Yang T

更新日期：2018-09-05 00:00:00

abstract：:Osteoclasts play a crucial role in osteolytic bone diseases, such as osteoporosis, rheumatoid arthritis, periodontitis, Paget's disease of bone and bone metastatic tumors. Therefore, controlling osteoclast differentiation and function has been considered a promising therapeutic strategy. Here, we show that necrostatin...

journal_title：Biochemical and biophysical research communications

authors： Fuji H,Ohmae S,Noma N,Takeiri M,Yasutomi H,Izumi K,Ito M,Toyomoto M,Iwaki S,Takemoto K,Seo S,Taura K,Hida S,Aoyama M,Ishihama Y,Hagiwara M,Takeda N,Hatano E,Iwaisako K,Uemoto S,Asagiri M

更新日期：2018-09-05 00:00:00

abstract：:Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Incre...

journal_title：Biochemical and biophysical research communications

authors： Pan YH,Yang M,Liu LP,Wu DC,Li MY,Su SG

更新日期：2018-09-05 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance, dyslipidemia and a systemic pro-inflammatory response, a leading cause of cirrhosis and hepatocellular carcinoma. Here, we showed that PDZ-LIM domain-containing protein 2 (PDLIM2) was an effective suppressor of steatoh...

journal_title：Biochemical and biophysical research communications

authors： Hao YR,Tang FJ,Zhang X,Wang H

更新日期：2018-09-05 00:00:00

abstract：:Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the p...

journal_title：Biochemical and biophysical research communications

authors： Fan XD,Wan LL,Duan M,Lu S

更新日期：2018-09-05 00:00:00

abstract：:Activation of protein kinase C delta (PKCδ) has been linked to the neuroinflammation but the relationship with the various neurodegenerative diseases including the Alzheimer's disease (AD) was mostly elusive. In the AD brains, the special phospholipids, ethanolamine plasmalogens (Pls), were found to be reduced and our...

journal_title：Biochemical and biophysical research communications

authors： Sejimo S,Hossain MS,Akashi K

更新日期：2018-09-05 00:00:00

abstract：:SIRT5 is one of the seven mammalian sirtuins which are NAD+-dependent deacylases. In human beings, SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4. Previous studies have focused mostly on SIRT5iso1. Characteristics regarding localization, activity and tissue di...

journal_title：Biochemical and biophysical research communications

authors： Du Y,Hu H,Hua C,Du K,Wei T

更新日期：2018-09-05 00:00:00

abstract：:Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the ...

journal_title：Biochemical and biophysical research communications

authors： Cai ZY,Yang B,Shi YX,Zhang WL,Liu F,Zhao W,Yang MW

更新日期：2018-09-05 00:00:00

abstract：:Hippo pathway regulates cell proliferation and differentiation. Yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) are effectors of Hippo pathway. The function of Yap/Taz in embryonic liver development has yet to be reported. Here yap1 and taz were found expressed in liver and ot...

journal_title：Biochemical and biophysical research communications

authors： Yi X,Yu J,Ma C,Li L,Luo L,Li H,Ruan H,Huang H

更新日期：2018-09-03 00:00:00

abstract：:Lung metastasis is a primary obstacle in the clinical treatment of metastatic breast cancer. Most patients with lung metastasis eventually die of recurrence. Recurrence may be related to self-seeding, which occurs when circulating tumor cells re-seed into the tumors they originated from (metastasis or carcinoma in sit...

journal_title：Biochemical and biophysical research communications

authors： Huang H,Zheng X,Cai C,Yao Z,Lu S,Meng X,Miao Y,He Z,Cai C,Zou F

更新日期：2018-09-03 00:00:00

abstract：:Circular RNA (circRNA) belongs to the non-coding RNA family and is involved in various human cancers, such as lung cancer and colorectal cancer. Nevertheless, whether circRNA expression is related to chronic lymphocytic leukemia (CLL) progression remains largely unclear. In our study, we investigated the role of circ-...

journal_title：Biochemical and biophysical research communications

authors： Xia L,Wu L,Bao J,Li Q,Chen X,Xia H,Xia R

更新日期：2018-09-03 00:00:00